Statin use ‘may modestly reduce Parkinson’s risk’

Regular use of cholesterol-lowering statin drugs may be associated with a modest reduction in the risk of developing Parkinson’s disease, particularly among younger patients, a new study has claimed. Statins are one of the most prescribed classes of drugs in the United States and some researchers have hypothesized that the anti-inflammatory and immunomodulating effects of these medications may be neuroprotective. However, statins also may have unfavourable effects on lowering the level of plasma coenzyme Q10, which may be neuroprotective in patients with Parkinson disease (PD), the researchers write in their study background. Xiang Gao and colleagues from the Brigham and Women’s Hospital and Harvard School of Public Health, Boston conducted a prospective study that included 38,192 men and 90,874 women participating in the Health Professional Follow-up study and the Nurses’ Health study. During 12 years of follow-up from 1994 to 2006, researchers documented 644 incident PD cases (338 in women and 306 in men). “In summary, we observed an association between regular use of statins and lower risk of developing PD, particularly among younger patients,” the researchers said. “However, our results should be interpreted with caution because only approximately 70 percent of users of cholesterol-lowering drugs at baseline were actual statin users. Further, the results were only marginally significant and could be due to chance,” they said. The researchers note that because they classified the use of any cholesterol-lowering drugs before 2000 as statin use, misclassification was inevitably introduced. They also did not collect information on the use of specific statins, which could have different effects on the central nervous system. When researchers did observe a significant interaction between statin use and age in relation to PD risk it was among study participants younger than 60 years at the start of follow-up, not among those participants who were older. The authors noted that not only have epidemiologic studies produced mixed results on statin use and PD risk, but statins also may have unfavourable effects on the central nervous system. “In contrast with use of ibuprofen, which has been consistently found to be inversely associated with PD risk in these cohorts as well as in other longitudinal studies, the overall epidemiological evidence relating stain use to PD risk remains unconvincing. “Given the potential adverse effects of statins, further prospective observational studies are needed to explore the potential effects of different subtypes of statin on risk of PD and other neurodegenerative diseases,” they added. The study has been published in Archives of Neurology.